Journal article
Breathlessness across generations: Results from the RHINESSA generation study
M Ekström, A Johannessen, MJ Abramson, B Benediktsdottir, K Franklin, T Gislason, F Gómez Real, M Holm, C Janson, R Jogi, A Lowe, A Malinovschi, J Martínez-Moratalla, A Oudin, JL Sánchez-Ramos, V Schlünssen, C Svanes
Thorax | BMJ PUBLISHING GROUP | Published : 2022
Abstract
Background Breathlessness is a major cause of suffering and disability globally. The symptom relates to multiple factors including asthma and lung function, which are influenced by hereditary factors. No study has evaluated potential inheritance of breathlessness itself across generations. Methods We analysed the association between breathlessness in parents and their offspring in the Respiratory Health in Northern Europe, Spain and Australia generation study. Data on parents and offspring aged ≥18 years across 10 study centres in seven countries included demographics, self-reported breathlessness, asthma, depression, smoking, physical activity level, measured Body Mass Index and spirometry...
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Awarded by Epidermolysis Bullosa Medical Research Foundation
Funding Acknowledgements
ME was supported by unrestricted grants from the Swedish Society for Medical Research and the Swedish Research Council (Dnr: 2019-02081). Coordination and establishment of the Respiratory Health in Northern Europe, Spain and Australia (RHINESSA) study has received funding from the Research Council of Norway (grant numbers 274767, 214123, 228174, 230827 and 273838), ERC StG project BRuSH (#804199), the European Union's Horizon 2020 research and innovation programme (grant agreement number 633212) (the ALEC Study WP2), the Bergen Medical Research Foundation and the Western Norwegian Regional Health Authorities (grant numbers 912011, 911892 and 911631). Study centres have further received local funding from the following: Bergen: the above grants, World University Network (REF and Sustainability grants), Norwegian Labour Inspection, the Norwegian Asthma and Allergy Association. Albacete and Huelva: Sociedad Espanola de Patologia Respiratoria (SEPAR) Fondo de Investigacion Sanitaria (FIS PS09). Goteborg, Umea and Uppsala: the Swedish Heart and Lung Foundation, the Swedish Asthma and Allergy Association. Reykjavik: Iceland University. Melbourne: NHMRC Project Grant ID 11282450, Melbourne University. Tartu: the Estonian Research Council (grant number PUT562). Arhus: The Danish Wood Foundation (grant number 444508795), the Danish Working Environment Authority (grant number 20150067134), Aarhus University (PhD scholarship). The RHINE study has received funding from Danish Lung Association, Estonian Science Foundation, Icelandic Research Council, Norwegian Research Council, Norwegian Asthma and Allergy Association, Swedish Asthma and Allergy Association, Swedish Heart and Lung Foundation and Vardal Foundation for Health Care Science and Allergy Research. The coordination of the ECRHS has been supported by the European Union's Horizon 2020 research and innovation programme (grant agreement number 633212) (the ALEC study), the Medical Research Council (ECRHS III) and the European Commission FP5 and FP7 (ECRHS I and II). ECRHS IV is being planned and the 10 RHINESSA study centres are funded by ERC StG project BRuSH (#804199) and by the European Union's Horizon 2020 research and innovation programme (grant agreement number 874703) (the EPHOR project). Further funding agencies for ECRHS are reported elsewhere.